Poison Spells 5e [DnD]

There are 10 poison spells in DnD 5e. The classes with the most poison spells include Wizards (9), Sorcerers (8), Bards (2), Druids (2), and Warlocks (2).

Here is a list of all the poison spells in DnD 5e from the game’s three main sourcebooks for spells (Player’s Handbook, Xanathar’s Guide to Everything, and Tasha’s Cauldron of Everything).

Poison Spells in 5e

Spell Name	Level	Save	Classes	Source
Infestation	0 (cantrip)	Constitution	Druid Sorcerer Warlock Wizard	XGtE
Poison Spray	0 (cantrip)	Constitution	Druid Sorcerer Warlock Wizard Artificer	PHB
Ray Of Sickness	1st-level	Constitution	Sorcerer Wizard	PHB
Cloudkill	5th-level	Constitution	Sorcerer Wizard	PHB

Additionally, several spells can deal Poison damage:

Spells that Can Deal Poison Damage

Spell Name	Level	Damage types	Save	Classes
Chaos Bolt	1st-level	acid cold fire force lightning poison psychic thunder		Sorcerer
Chromatic Orb	1st-level	acid cold fire lightning poison thunder		Sorcerer Wizard
Dragon’s Breath	2nd-level	acid cold fire lightning poison	Dexterity	Sorcerer Wizard
Prismatic Spray	7th-level	acid cold fire lightning poison	Dexterity	Bard Sorcerer Wizard
Illusory Dragon	8th-level	acid cold fire lightning necrotic poison	Intelligence	Wizard
Prismatic Wall	9th-level	acid cold fire lightning poison	Dexterity	Bard Wizard

As you can see, all the straight-up poison spells require a Constitution saving throw.

Monster Interactions with poison Spells

207 creatures are immune to poison damage, 21 are resistant to it, and 0 are vulnerable to it. This is based on the 818 creatures in DnD 5e’s main monster sourcebooks (Monster Manual, Volo’s Guide to Monsters, Mordenkainen’s Tome of Foes, Fizban’s Treasury of Dragons).

Poison damage is the most resisted damage type in the game.